The partition coefficients of 133 Xe between blood and haematopoietic bone marrow and homogenised bone have been determined in vitro. International Nuclear Information System (INIS) The partition coefficients of 133Xe between blood and bone The coefficients varied from bladder to bladder owing to small differences. In four landrace pigs the tissue/blood partition coefficient (lambda) for xenon (Xe) for the urinary bladder was calculated after chemical analysis for lipid, water and protein content and determination of the haematocrit. Xenon tissue/blood partition coefficient for pig urinary bladder The observed lipid-normalized algae–water distribution coefficients (log K aw/lipid ) are virtually identical to the respective log K tw values, which manifests the dominant lipid- partition effect of the compounds with algae The PDMS-gas partition coefficients were well correlated to the molecular weight of organic compounds (r = 0.832, p âˆ❅, which is attributed to the presence and absence of a triolein microemulsion in water affecting the solute partitioning. The effect of physicochemical properties and descriptors on the partitioning process of partition coefficients was explicated by the correlation analysis. Prediction of Partition Coefficients of Organic Compounds for SPME/PDMSĭirectory of Open Access Journals (Sweden)įull Text Available The partition coefficients of 51 organic compounds between SPME/PDMS and gas were compiled from the literature sources in this study. It is also shown how calculated hydrogen bond basicity can be used to model the effect of aromatic aza-substitution on octanol/water partition coefficients. Aligned hydrogen bond acceptors appear to present special challenges for prediction of alkane/water partition coefficients and this may reflect `frustration' of solvation resulting from overlapping hydration spheres. Relationships between polarity and calculated hydrogen bond basicity are derived for aromatic nitrogen and carbonyl oxygen. Analysis of alkane/water partition coefficients in conjunction with molecular electrostatic potential calculations suggests that aromatic chloro substituents may be less lipophilic than is generally believed and that some of the effect of chloro-substitution stems from making the aromatic Ï€-cloud less available to hydrogen bond donors. When polarity is defined in this manner, hydrogen bond donors are typically less polar than hydrogen bond acceptors. It is shown how polarity of both compounds and substructures can be estimated from measured alkane/water partition coefficients. This Perspective explores how consideration of hydrogen bonding can be used to both predict and better understand partition coefficients. The influence of hydrogen bonding on partition coefficientsīorges, Nádia Melo Kenny, Peter W.
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